BDBM130354 US8822534, Example 5-4::US8993631, 5-2

SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(F)c1

InChI Key InChIKey=GKNJPJZPAMDYBU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 130354   

TargetMembrane metallo-endopeptidase-like 1(Human)
Novartis

US Patent
LigandPNGBDBM130354(US8822534, Example 5-4 | US8993631, 5-2)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2015
Entry Details
Go to US Patent

TargetMembrane metallo-endopeptidase-like 1(Human)
Novartis

US Patent
LigandPNGBDBM130354(US8822534, Example 5-4 | US8993631, 5-2)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2015
Entry Details
Go to US Patent

TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130354(US8822534, Example 5-4 | US8993631, 5-2)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed