BDBM12963 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-2-({[(2,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 23

SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#7]-[#6]-c1ccc(Cl)cc1Cl)-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-c1nccs1

InChI Key InChIKey=RAVHEFBRDCXZHI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 12963   

TargetCoagulation factor X(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 1.30E+4nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 386nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 45nMAssay Description:Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2007
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human factor 11aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human alpha-thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Daiichi Asubio Medical Research Laboratories

LigandPNGBDBM12963((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed