BDBM126500 US11591322, Compound NVP-2::US8778951, 310

SMILES COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1

InChI Key InChIKey=XWQVQSXLXAXOPJ-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 126500   

TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 706nMAssay Description:Inhibition of CDK2 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 350nMAssay Description:Inhibition of DYRK1B (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 18(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of CDK18 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 17(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CDK17 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 16(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 605nMAssay Description:Inhibition of CDK16 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 14(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 3.45E+3nMAssay Description:Inhibition of CDK14 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK7 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of CDK5 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Novartis

US Patent
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 0.000300nMAssay Description:Cdk9/cyclinT1 is purchased from Millipore, cat #14-685. The final total protein concentration in the assay 4 nM. The 5TAMRA-cdk7tide peptide substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2014
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 584nMAssay Description:Inhibition of CDK1 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 0.514nMAssay Description:Inhibition of CDK9 (unknown origin) by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Novartis

US Patent
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 3.75nMAssay Description:To each well of a 96-well plate was added 5× kinase assay buffer with 10 mM DTT (6 μL), 500 μM ATP (1 μL), 5×CDK substrate (10 μL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK2/cyclinA2 expressed in baculovirus infected Sf9 insect cells using histone H1 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCyclin-K(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged CDK9/cyclinK expressed in baculovirus infected Sf9 insect cells using PDKtide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM126500(US8778951, 310 | US11591322, Compound NVP-2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged CDK6/cyclinD3 expressed in baculovirus infected Sf9 insect cells using histone H1 a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed