BDBM12569 GTC000006A::N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-2-oxobutane-1-sulfonamido::pyrrolidin-2-one-based inhibitor 28

SMILES CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1

InChI Key InChIKey=DSPUJUOXCWMCJY-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12569   

TargetCoagulation factor X(Human)
D3R/Abbott

LigandPNGBDBM12569(N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(mo...)
Affinity DataIC50: 6.40nMAssay Description:D3R245More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2017
Entry Details
D3R

TargetCoagulation factor X(Human)
D3R/Abbott

LigandPNGBDBM12569(N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(mo...)
Affinity DataIC50: 1.11nMAssay Description:D3R246More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2017
Entry Details
D3R

TargetCoagulation factor X(Human)
D3R/Abbott

LigandPNGBDBM12569(N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(mo...)
Affinity DataKi:  1nM ΔG°:  -12.3kcal/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2006
Entry Details Article
PubMed