BDBM124190 US8748451, 5

SMILES ONC(=O)c1ccc(Cn2c3ccccc3c3ccccc23)cc1

InChI Key InChIKey=CASUOFRPUDPLQN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 124190   

TargetHistone deacetylase 1(Human)
University of Illinois

US Patent
LigandPNGBDBM124190(US8748451, 5)
Affinity DataIC50: 1.09E+4nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM124190(US8748451, 5)
Affinity DataIC50: 19nMpH: 8.0 T: 2°CAssay Description:HDAC assay is performed using fluorescently-labeled acetylated substrate, which comprises an acetylated lysine side chain. After incubation with HDAC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2014
Entry Details
Go to US Patent

TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM124190(US8748451, 5)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Illinois

US Patent
LigandPNGBDBM124190(US8748451, 5)
Affinity DataIC50: 40nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC6 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
European Molecular Biology Laboratory

Curated by ChEMBL
LigandPNGBDBM124190(US8748451, 5)
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed