BDBM123781 3-(aminomethyl)-2-(2-methylpropyl)-1-oxo-4- phenylisoquinoline-6-carboxamide (21)::CHEMBL1812901

SMILES CC(C)Cn1c(CN)c(-c2ccccc2)c2cc(ccc2c1=O)C(N)=O

InChI Key InChIKey=UIKDPMGTFQHKLC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 123781   

TargetDipeptidyl peptidase 4(Human)
China Pharmaceutical University

LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 360nMAssay Description:The HypoGen module in DS2.5 was employed to produce pharmaphores with the training set compounds.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
China Pharmaceutical University

LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human DPP4 isolated from human CaCo2 cells incubated for 15 mins using Gly-Pro-pNA.Tos substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 550nMAssay Description:Inhibition of DPP4 in rat plasma incubated for 60 mins using H-lys-Ala-pNA.2HCl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Rat)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of DPP4 in rat spleen incubated for 60 mins using H-lys-Ala-pNA.2HCl substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Bovine)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of bovine spleen cathepsin CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
China Pharmaceutical University

LigandPNGBDBM123781(CHEMBL1812901 | 3-(aminomethyl)-2-(2-methylpropyl)...)
Affinity DataIC50: 360nMAssay Description:Inhibition of human DPP4 purified from Caco2 cells pre-incubated for 15 mins before Gly-Pro-pNA substrate addition and measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2019
Entry Details Article
PubMed