BDBM123515 US8748435, 40

SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(\C=C\CN2CCN(CC2)C(C)C)cc1

InChI Key InChIKey=UAMIBPKKKLTAKG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 123515   

TargetG-protein coupled receptor 4(Human)
Novartis

US Patent
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 55nMpH: 8.0Assay Description:Serial dilutions of compounds (stock in 10 mM DMSO) are prepared by first diluting the compounds in DMSO followed by a 1:50 dilution into assay buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2014
Entry Details
Go to US Patent

TargetG-protein coupled receptor 4(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 1.29E+3nMAssay Description:Antagonist activity at mouse GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetG-protein coupled receptor 4(Human)
Novartis

US Patent
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human GPR4 expressed in African green monkey COS7 cells assessed as inhibition of pH 6.5-induced cAMP accumulation after 30 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 930nMAssay Description:Antagonist activity at histamine H3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetG-protein coupled receptor 4(Rat)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 800nMAssay Description:Antagonist activity at rat GPR4 expressed in HEK cells assessed as inhibition of pH-induced cAMP accumulation preincubated for 15 mins followed by cA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed
TargetG-protein coupled receptor 4(Human)
Novartis

US Patent
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 114nMAssay Description:Antagonist activity at human GPR4 expressed in human HeLa cells assessed as inhibition of IBMX-induced cAMP accumulation after 15 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 930nMAssay Description:Displacement of [3H]-R(-)-alpha-Methyl[imidazole-2.5(n)]histamine from human recombinant histamine H3 receptor expressed in CHOK1 cell membranes afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM123515(US8748435, 40)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [3H]-dofetilide from recombinant human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2020
Entry Details Article
PubMed