BDBM122536 US8735593, I-4

SMILES Cc1cc(nc(Nc2n[nH]c3ncc(F)cc23)c1C)-c1ccccc1Cl

InChI Key InChIKey=ZHZPUYSNZQKXRF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 122536   

TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122536(US8735593, I-4)
Affinity DataIC50: 300nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM122536(US8735593, I-4)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Compounds of the present invention were screened for their ability to inhibit GSK-3β (AA 1-420) activity using a standard coupled enzyme system ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2014
Entry Details
Go to US Patent