BDBM120979 US8716285, 36

SMILES CN(C1CCc2ccc(cc2C1)C(=O)NO)c1nccc(n1)-c1cccnc1

InChI Key InChIKey=DZFHQEGFDAYUAR-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120979   

TargetHistone deacetylase 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM120979(US8716285, 36)
Affinity DataIC50: 3.04E+3nMAssay Description:Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM120979(US8716285, 36)
Affinity DataEC50:  2.25E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed