BDBM120947 US8716285, 4

SMILES ONC(=O)c1ccc2CCC(Cc2c1)Nc1ccc(C#N)c(Cl)c1

InChI Key InChIKey=VBBLVDIRGKUPNB-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 120947   

TargetHistone deacetylase 8(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM120947(US8716285, 4)
Affinity DataIC50: 3.73E+3nMAssay Description:Compounds were tested for their ability to inhibit histone deacetylase 8 using an in vitro deacetylation assay. In a detailed procedure, 8 μl o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 6(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM120947(US8716285, 4)
Affinity DataEC50:  460nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed