BDBM12075 (2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-methylbutanoic acid::CHEMBL43152::alpha-arylsulfonylamino carboxylate 2S

SMILES CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Br)cc1)C(O)=O

InChI Key InChIKey=GJOCABIDMCKCEG-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 12075   

Target72 kDa type IV collagenase(Human)
Istituto Di Cristallografia

LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 4nMpH: 7.0 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 8nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibition of recombinant human matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 7.90E+3nMAssay Description:In vitro inhibition of matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of human recombinant matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Istituto Di Cristallografia

LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 7.20E+3nMAssay Description:In vitro inhibition of matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 7.94E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Indian Institute of Technology (Bhu)

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 240nMAssay Description:Inhibition of MMP14 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 12nMAssay Description:Inhibition of MMP3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 8nMAssay Description:Inhibition of MMP13 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Istituto Di Cristallografia

LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataIC50: 47nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM12075(CHEMBL43152 | (2S)-2-{[4-(4-bromophenyl)benzene]su...)
Affinity DataKi:  4.40nM ΔG°:  -11.4kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2006
Entry Details Article
PubMed