BDBM119382 US8669361, 105::US9573943, Example 105

SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1NCC1CCNCC1

InChI Key InChIKey=QVHWRVHLJFUJKP-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 119382   

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  4.54nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  4.54nM ΔG°:  -11.4kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  5.77nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  5.77nM ΔG°:  -11.2kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  148nMpH: 7.2Assay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM119382(US8669361, 105 | US9573943, Example 105)
Affinity DataKi:  148nM ΔG°:  -9.31kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In DepthDetails
US Patent