BDBM116227 US10035794, Example 1::US10683287, Example 1::US8637508, 1

SMILES C[C@]1(COCC(N)=N1)c1cccc(NC(=O)c2ccc(Br)cn2)n1

InChI Key InChIKey=WQUQHUCOJVZXJC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 116227   

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 390nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 260nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 390nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 260nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 41nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 1(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 390nMAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetBeta-secretase 2(Human)
Novartis

US Patent
LigandPNGBDBM116227(US8637508, 1 | US10035794, Example 1 | US10683287,...)
Affinity DataIC50: 260nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails
US Patent