BDBM115182 N‐(4‐ethoxyphenyl)‐8‐methoxy‐2‐(piperidine‐1‐ carbonyl)quinolin‐4‐amine::UT-A1 inhibitor A1

SMILES CCOc1ccc(Nc2cc(nc3c(OC)cccc23)C(=O)N2CCCCC2)cc1

InChI Key InChIKey=DGRFWSAHPXCNDD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 115182   

TargetUrea transporter 2(Rat)
University of California San Francisco

LigandPNGBDBM115182(N‐(4‐ethoxyphenyl)‐8‐metho...)
Affinity DataIC50: 3.30E+3nMAssay Description:The urea concentration dependence of UT-A1 inhibition was studied from inhibitor concentration response data (0.3 - 60 µM) using different of ur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed
TargetUrea transporter 1(Rat)
University of California San Francisco

LigandPNGBDBM115182(N‐(4‐ethoxyphenyl)‐8‐metho...)
Affinity DataIC50: 1.60E+4nMAssay Description:Erythrocyte suspension (100 µL) was added to each well of a 96-well microplate to which test compounds were added. After 15 min incubation, 20 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2014
Entry Details Article
PubMed
TargetUrea transporter 1(Mouse)
National University of Pharmacy

Curated by ChEMBL
LigandPNGBDBM115182(N‐(4‐ethoxyphenyl)‐8‐metho...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of UT-B in mouse erythrocyte incubated for 15 mins by erythrocyte osmotic lysis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed