BDBM11297 4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitropyridine-3-carbonitrile::Compound 1 analog 8::acs.jmedchem.1c00409_ST.544::cid_2726176

SMILES Cc1ccc(cc1)S(=O)(=O)c1nc(C)c(c(C)c1C#N)[N+]([O-])=O

InChI Key InChIKey=SWVOLMFAZXVBNL-UHFFFAOYSA-N

Data  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 11297   

TargetReplicase polyprotein 1ab(SARS-CoV)
National Defense Medical Center

LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataIC50: 1.30E+4nMpH: 7.0 T: 2°CAssay Description:The effects of compound on enzyme activity were measured by using a fluorogenic peptide cleavage assay. Enhanced fluorescence caused by cleavage of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2006
Entry Details Article
PubMed
TargetVacuolar aminopeptidase 1(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataEC50:  4.17E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2011
Entry Details
PCBioAssay
TargetMitochondrial import inner membrane translocase subunit TIM10(Baker's yeast)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataIC50: 4.55E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2011
Entry Details
PCBioAssay
TargetMitochondrial import inner membrane translocase subunit TIM23(Baker's yeast)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataIC50: 2.08E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/3/2011
Entry Details
PCBioAssay
TargetReplicase polyprotein 1ab(SARS-CoV)
National Defense Medical Center

LigandPNGBDBM11297(4,6-dimethyl-2-[(4-methylbenzene)sulfonyl]-5-nitro...)
Affinity DataIC50: 1.30E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2022
Entry Details Article
PubMed