BDBM111844 US8623906, XW2-057::US9174969, XW2-057

SMILES CCC(=O)N1CCc2cc(ccc12)S(=O)(=O)N1CCN(CC1)c1cccc(C)c1

InChI Key InChIKey=XTFFEPBZKAWRGW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111844   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM111844(US8623906, XW2-057 | US9174969, XW2-057)
Affinity DataIC50: 3.40E+3nMAssay Description:In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM111844(US8623906, XW2-057 | US9174969, XW2-057)
Affinity DataIC50: 3.40E+3nMAssay Description:IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. More data for this Ligand-Target Pair
In DepthDetails
US Patent