BDBM110999 US8614253, 26-1::US8614253, 3-30::US9241942, 3-30::US9963434, Compound 3-30

SMILES COc1cc(cc(C=O)c1O)-c1ccncc1

InChI Key InChIKey=HAODQXIJMBNKBB-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 110999   

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataIC50: 580nMpH: 7.5 T: 2°CAssay Description:IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataIC50: 104nMpH: 7.5 T: 2°CAssay Description:IRE-1 alpha, T1 RNase, and RNase A assays carried out in vitro with several o-vanillin derivatives to demonstrate selectivity of the derivatives for ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataIC50: 580nMpH: 7.5Assay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) was obtained from a 500 ml baculovirus-infected i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataIC50: 104nMpH: 7.5Assay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) was obtained from a 500 ml baculovirus-infected i...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataEC50:  7.00E+4nMAssay Description:Initial cell-based XBP-1 mRNA splicing assays confirmed IRE-1α inhibition with several potent 5-bromo and 6 bromo o-vanillins. HEK293 cells were...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM110999(US8614253, 26-1 | US8614253, 3-30 | US9241942, 3-3...)
Affinity DataIC50: 580nMAssay Description:A fusion protein comprising glutathione S transferase (GST) and human IRE-1α (GST-IRE-1α) was obtained from a 500 ml baculovirus-infected i...More data for this Ligand-Target Pair
In DepthDetails
US Patent