BDBM109907 US20240150367, Compound 52::US8609647, 52

SMILES O=C(NCC#N)N1CCCC11CCCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=SZMFRSIFZYFUHP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 109907   

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109907(US8609647, 52 | US20240150367, Compound 52)
Affinity DataIC50: 10nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109907(US8609647, 52 | US20240150367, Compound 52)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109907(US8609647, 52 | US20240150367, Compound 52)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Japan Tobacco

US Patent
LigandPNGBDBM109907(US8609647, 52 | US20240150367, Compound 52)
Affinity DataIC50: 10nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent