BDBM109867 US20240150367, Compound 5::US8609647, 27::US8609647, 37::US8609647, 5

SMILES FC1(F)CN(C(=O)CC#N)C11CCCN(C1)c1ncnc2[nH]ccc12

InChI Key InChIKey=VUHWQBJVFDDFAF-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 109867   

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 4nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 88nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 3.30nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 1.90nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2014
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected Sf9 cells using TK-substrate-biotin as substrate incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human Lck using TK-substrate-biotin as substrate incubated for 60 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 4nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 88nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 3.30nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK3 kinase domain (aa781-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Japan Tobacco

US Patent
LigandPNGBDBM109867(US8609647, 27 | US8609647, 37 | US8609647, 5 | US2...)
Affinity DataIC50: 1.90nMAssay Description:In the kinase reactions, fused proteins (6His tag-fused hJAK2 kinase domain (aa808-end)) which were coexpressed in Sf21 cells and purified by Ni2+/NT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent