BDBM10925 3-{[methyl({3-[(2-oxo-2H-chromen-7-yl)oxy]propyl})amino]methyl}phenyl N-heptylcarbamate hydrochloride::CHEMBL440526::aminoalkoxyheteroaryl deriv. 18

SMILES CCCCCCCNC(=O)Oc1cccc(CN(C)CCCOc2ccc3ccc(=O)oc3c2)c1

InChI Key InChIKey=FTRXEEOTFGUKHN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 10925   

TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 13nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 65nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2006
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Bologna

LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Bologna

LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 161nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 29nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 620nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Alma Mater Studiorum-University of Bologna

Curated by ChEMBL
LigandPNGBDBM10925(CHEMBL440526 | 3-{[methyl({3-[(2-oxo-2H-chromen-7-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed