BDBM107767 US11419874, PF-05180999::US8598155, 2

SMILES Cc1nc(-c2cnn(C)c2-c2ccc(cn2)C(F)(F)F)c2c(ncnn12)N1CCC1

InChI Key InChIKey=CLGCHUKGBICQTE-UHFFFAOYSA-N

Data  1 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 107767   

LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1.61nMAssay Description:The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
Go to US Patent

LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length PDE2a using cGMP as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2019
Entry Details Article
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length human N-terminal FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate after 30 mins by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2019
Entry Details Article
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2019
Entry Details Article
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1.61nMAssay Description:Isolated cardiomyocytes were washed twice in PBS at room temperature, transferred to 4% paraformaldehyde (PFA) and gently shaken for 30 min, then was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2022
Entry Details
Go to US Patent

LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
LigandPNGBDBM107767(US8598155, 2 | US11419874, PF-05180999)
Affinity DataKi:  4.20nMAssay Description:Displacement of radiolabeled 4-(azetidin-1-yl)-3-[5-[4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl]-1-(tritritiomethyl)pyrazolo[3,4-d]pyrimidine from PD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2019
Entry Details Article
PubMed