BDBM106706 CHEMBL1957356::US8586620, 64

SMILES CN1CCC(=CC1)c1c[nH]c2ccc(NC(=S)NC(=O)c3ccccc3)cc12

InChI Key InChIKey=WLVQDSCVFJYKIP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 106706   

TargetNitric oxide synthase, brain(Human)
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50: 1.40E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, endothelial(Human)
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50: 4.30E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

Target5-hydroxytryptamine 1D receptor(Bovine)
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50: 56nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Neuraxon

US Patent
LigandPNGBDBM106706(CHEMBL1957356 | US8586620, 64)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed