BDBM106699 CHEMBL1957350::US8586620, 46

SMILES CN1CCC(=CC1)c1c[nH]c2ccc(cc12)N=C(N)c1ccco1

InChI Key InChIKey=FGOJTWGOHRIUFP-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 106699   

TargetNitric oxide synthase, brain(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 1.78E+3nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, endothelial(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 5.40E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, inducible(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 5.80E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

Target5-hydroxytryptamine 1D receptor(Bovine)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 50nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2014
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 550nMAssay Description:Inhibition of human nNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 3.61E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, inducible(Human)
Neuraxon

US Patent
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 5.85E+4nMAssay Description:Inhibition of human iNOS expressed in baculovirus infected insect Sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrullineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 9.52E+3nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Neuraxon

Curated by ChEMBL
LigandPNGBDBM106699(CHEMBL1957350 | US8586620, 46)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of rat nNOSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed