BDBM104083 (Z)-5-(4-((4-Ethylphenyl)thio)-3-nitrobenzylidene)-2- thioxothiazolidin-4-one 17::DNA polymerase inhibitor 17

SMILES CCc1ccc(Sc2ccc(C=C3SC(S)=NC3=O)cc2[N+]([O-])=O)cc1

InChI Key InChIKey=WXUBELMQXKIUPU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 104083   

TargetDNA polymerase beta(Human)
University of Konstanz

LigandPNGBDBM104083((Z)-5-(4-((4-Ethylphenyl)thio)-3-nitrobenzylidene)...)
Affinity DataIC50: 5.00E+4nMpH: 7.9Assay Description:Pol β reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.9, 20mM KCl, 5% (v/v) glycerol, 1mM DTT, 2mM MnCl2, 250nM puri...More data for this Ligand-Target Pair
In DepthDetails Article
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TargetDNA polymerase lambda(Human)
University of Konstanz

LigandPNGBDBM104083((Z)-5-(4-((4-Ethylphenyl)thio)-3-nitrobenzylidene)...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Pol λ reactions were made in a final volume of 20uL containing 50mM Tris-HCl pH 7.5, 1.5mM MgCl2, 5% (v/v) glycerol, 1mM DTT, 250nM purified rec...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed