BDBM103925 US8569511, 9

SMILES FC1(F)CC1C(=O)Nc1ccc2[nH]nc(-c3nc4ccc(CN5CCOCC5)cc4[nH]3)c2c1

InChI Key InChIKey=UJAQOAKVBADEOD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 103925   

Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM103925(US8569511, 9)
Affinity DataIC50: 3.75E+3nMAssay Description:The primary assay for compound inhibitory activity was the ATP depletion assay using the PDKtide substrate purchase from Millipore Corporation.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2014
Entry Details
Go to US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM103925(US8569511, 9)
Affinity DataIC50: 1.22E+3nMAssay Description:The secondary assay was a time resolved-FRET LanthaScreen Kinase Binding Assay. (Invitrogen Corporation, Carlsbad, Calif.). This assay evaluates the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2014
Entry Details
Go to US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
University of Utah Research Foundation

US Patent
LigandPNGBDBM103925(US8569511, 9)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PDK1 (unknown origin) after 1 hr in presence of Ser/Thr-07 by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed