BDBM10325 (S)-1-(Carboxymethyl)-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin::2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indol-1-yl)acetic acid::Isatin Sulfonamide 36

SMILES OC(=O)CN1C(=O)C(=O)c2cc(ccc12)S(=O)(=O)N1CCC[C@H]1COc1ccccc1

InChI Key InChIKey=NWBGMXDBUUPYMX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10325   

TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10325(2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)pyrrolidine...)
Affinity DataIC50: 170nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2006
Entry Details Article
PubMed
TargetCaspase-3(Human)
Glaxosmithkline

LigandPNGBDBM10325(2-(2,3-dioxo-5-{[(2S)-2-(phenoxymethyl)pyrrolidine...)
Affinity DataIC50: 170nMAssay Description:Inhibition of caspase 3 in human SK-N-SH cells assessed as accumulation of fluorogenic 7-amino-4-methyl coumarin by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed