BDBM10111 (3Z)-5-fluoro-4-[2-(4-hydroxypiperidin-4-yl)ethynyl]-3-[(3-methoxy-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one hydrochloride::4-alkynyl oxindole 7q::ROCHE screening, 72

SMILES COc1cc[nH]c1\C=C1/C(=O)Nc2ccc(F)c(C#CC3(O)CCNCC3)c12

InChI Key InChIKey=OIINJADYHQPDPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 10111   

LigandPNGBDBM10111((3Z)-5-fluoro-4-[2-(4-hydroxypiperidin-4-yl)ethyny...)
Affinity DataIC50: 6nMpH: 7.5 T: 2°CAssay Description:Kinase assays were performed using a recombinant human cyclin E-CDK2 complex. The enzyme was assayed with substrate in the presence of 1uM ATP/[gamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2006
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Technical University of Dortmund

LigandPNGBDBM10111((3Z)-5-fluoro-4-[2-(4-hydroxypiperidin-4-yl)ethyny...)
Affinity DataIC50: 12nMAssay Description:IC50 determinations for TBK1 were performed with the KinEASE-STK assay from Cisbio according to the manufacturer's instructions. A biotinylated s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2015
Entry Details Article
PubMed