BDBM50005685 2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester::2,2-Diphenyl-propionic acid 2-diethylamino-ethyl ester(Aprophen)::2-(diethylamino)ethyl 2,2-diphenylpropanoate::Aprofene::Aprophen::CHEMBL26505

SMILES CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1

InChI Key InChIKey=DIDYGLSKVUKRRP-UHFFFAOYSA-N

Data  17 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50005685   

TargetPancreatic alpha-amylase(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataIC50: 46nMAssay Description:Inhibition of the release of Alpha-amylase from rat pancreatic acinar cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataIC50: 6.70E+3nMAssay Description:50 percent inhibitory concentration of Butyrylcholinesterase (BChE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity was determined from the inhibition of contraction of guinea pig ileum which has Muscarinic acetylcholine receptor M2 subtype.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  2.10nMAssay Description:Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M1 subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Rat)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  3.39nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor(Rabbit)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  4.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Chicken)
Glaxo Group Research

Curated by PDSP Ki Database
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2011
Entry Details
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  7.40nMAssay Description:Antimuscarinic potency and subset specificity was characterised by its inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M4 subt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  7.70nMAssay Description:Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M3 subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  9.30nMAssay Description:Antimuscarinic potency and subset specificity was characterised by inhibition of the [3H]NMS Binding to Muscarinic acetylcholine receptor M2 subtypeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  15.1nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  23nMAssay Description:Inhibit the binding of [N-mnethyl-3H]-scopolamine [3H]-NMS) to Muscarinic acetylcholine receptor of human IRM-30 neuroblastoma cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2018
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  26.5nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMuscarinic receptor M1(Bovine)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  51nMAssay Description:Inhibition of [3H]NMS binding to cerebral cortex membranes which contain predominantly the Muscarinic acetylcholine receptor M1 subtypesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  107nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M2 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M4(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  628nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M4 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Institute of Research

Curated by ChEMBL
LigandPNGBDBM50005685(Aprophen | 2-(diethylamino)ethyl 2,2-diphenylpropa...)
Affinity DataKi:  7.76E+3nMAssay Description:Displacement of [3H] N-methylscopolamine from human muscarinic M3 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMed