BDBM50009071 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-pentyloxy]-chroman-2-carboxylic acid::6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-pentyloxy]-chroman-2-carboxylic acid(Ro 23-3544)::Ablukast::CHEMBL22016::Ro-23-3544

SMILES CCCc1c(O)c(ccc1OCCCCCOc1cc2OC(CCc2cc1C(C)=O)C(O)=O)C(C)=O

InChI Key InChIKey=FGGYJWZYDAROFF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50009071   

TargetCysteinyl leukotriene receptor 1(Guinea pig)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50009071(Ro-23-3544 | 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-p...)
Affinity DataIC50: 4.00E+3nMAssay Description:Compound was evaluated for its ability to displace [3H]LTD4 from LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Ici Pharmaceuticals Group

Curated by ChEMBL
LigandPNGBDBM50009071(Ro-23-3544 | 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-p...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity of compound to block binding of [3H]leukotriene D4 to Cysteinyl leukotriene D4 receptor sites in homogenized guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Human)
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50009071(Ro-23-3544 | 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-p...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibitory activity to inhibit Inophore-induced arachidonic acid metabolism (inhibition of TXB2 formation) in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50009071(Ro-23-3544 | 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-p...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of bovine heart Phosphodiesterase 1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50009071(Ro-23-3544 | 6-Acetyl-7-[5-(4-acetyl-3-hydroxy-2-p...)
Affinity DataIC50: 4.00E+3nMAssay Description:Compound was tested for inhibitory activity against LTD4 (leukotriene).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2012
Entry Details Article
PubMed