BDBM50468245 AV-412::CHEMBL2138625::MP-412

SMILES CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

InChI Key InChIKey=ZAJXXUDARPGGOC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50468245   

TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | MP-412 | CHEMBL2138625)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | MP-412 | CHEMBL2138625)
Affinity DataIC50: 19nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | MP-412 | CHEMBL2138625)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | MP-412 | CHEMBL2138625)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | MP-412 | CHEMBL2138625)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed