BDBM50244430 9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)phenyl)-9H-purin-6-amine::AP24149::CHEMBL488840

SMILES Cc1cccc(C)c1\C=C\n1cnc2c(Nc3ccc(cc3)P(C)(C)=O)ncnc12

InChI Key InChIKey=RFSFIDGEFVXSQM-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50244430   

TargetVascular endothelial growth factor receptor 1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 591nMAssay Description:Inhibition of Flt1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 4(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of EphB4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 21nMAssay Description:Inhibition of c-RafMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-B receptor 1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of EphB1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FmsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human Src kinase by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEphrin type-A receptor 7(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of EphA1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 3.60nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 414nMAssay Description:Inhibition of KitMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 221nMAssay Description:Inhibition of PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 151nMAssay Description:Inhibition of Flt4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of InsRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIsoform 1 of Fibronectin (1)(Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 9.10nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1 [T315I](Human)
Ariad Pharmaceuticals

LigandPNGBDBM50244430(AP24149 | CHEMBL488840 | 9-(2,6-dimethylstyryl)-N-...)
Affinity DataIC50: 8.90E+3nMAssay Description:In vitro kinase assay using Abl, Abl T315I or Src kinase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed