BDBM50247892 AM-833::CHEBI:31810::Fleroxacin::Megalone::Ro-236240::Ro-236240000

SMILES CN1CCN(CC1)c1c(F)cc2c(c1F)n(CCF)cc(C(O)=O)c2=O

InChI Key InChIKey=XBJBPGROQZJDOJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50247892   

LigandPNGBDBM50247892(CHEBI:31810 | AM-833 | Fleroxacin | Megalone | Ro-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50247892(CHEBI:31810 | AM-833 | Fleroxacin | Megalone | Ro-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50247892(CHEBI:31810 | AM-833 | Fleroxacin | Megalone | Ro-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50247892(CHEBI:31810 | AM-833 | Fleroxacin | Megalone | Ro-...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetDNA gyrase subunit B(Staphylococcus aureus subsp. aureus Mu50)
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247892(CHEBI:31810 | AM-833 | Fleroxacin | Megalone | Ro-...)
Affinity DataIC50: 1.86E+5nMAssay Description:Inhibitory concentration against DNA gyrase of Staphylococcus aureusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed