BDBM4363 (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide::AG 213::CHEMBL77030::RG-50864::T7540 (Tyrphostin 47)::Tyrphostin A47::alpha-Cyano-(3,4-dihydroxy)thiocinnamide::benzylidenemalononitrile (BMN) deriv. 47

SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=ZGHQGWOETPXKLY-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 4363   

TargetMacrophage colony-stimulating factor 1 receptor [538-972]()
Johnson & Johnson Pharmaceutical

LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 2.90E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-678,753-922](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 3.30E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor [538-678,753-922](Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 3.00E+3nMpH: 7.5 T: 2°CAssay Description:The full-length cFMS cytoplasmic domain (FMS.538-972.6His) or chimera was incubated with compound in reaction buffer. Control reactions were run in e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 3.00E+3nMT: 2°CAssay Description:In order to eliminated fluorescence interference, chemicals were subjected to a secondary screening using colorimetric BP incorporation assay. TGase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetDynamin-1(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 7.00E+4nMAssay Description:Inhibitory activity against dynamin1 GTPase expressed in sheep brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human EGFR tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Freie UniversitäT Berlin

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human HER2 tyrosine kinase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of recombinant SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of EGF-dependent proliferation of human and guinea pig keratinocytes; range 7-15 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Institute of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataIC50: 6.40E+5nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM4363(alpha-Cyano-(3,4-dihydroxy)thiocinnamide | CHEMBL7...)
Affinity DataKi:  850nM IC50: 2.40E+3nMAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2005
Entry Details Article
PubMed