BDBM50232114 (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea::ABT-102::CHEMBL398338::N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea

SMILES CC(C)(C)c1ccc2[C@@H](CCc2c1)NC(=O)Nc1cccc2[nH]ncc12

InChI Key InChIKey=TYOYXJNGINZFET-UHFFFAOYSA-N

Data  1 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50232114   

LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 0.700nMpH: 5.5Assay Description:Blockade of pH 5.5-induced activation of TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 4nMAssay Description:Blockade of human TRPV1 receptor assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 3nMAssay Description:Blockade of N-arachidonoyl-dopamine-induced activation of TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity against human TRPV1 expressed in HEK293 cells assessed as capsaicin-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2016
Entry Details Article
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily V member 4(Human)
The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at TRPV4 (unknown origin) assessed as inhibition of capsaicin induced Ca2+ influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50232114(N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity at human TRPV1 expressed in CHO-K1 cells assessed as inhibition of capsaicin-induced Ca2+ response treated with compound 6 mins p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed