BDBM50250187 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)-benzenesulfonamide::A-867744::CHEMBL490153

SMILES CCC(=O)c1cc(-c2ccc(Cl)cc2)n(c1C)-c1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=ABACVOXFUHDKNZ-UHFFFAOYSA-N

Data  1 KI  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50250187   

TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataEC50:  1.10E+3nMAssay Description:Positive allosteric modulation at human alpha7 nACHR expressed in Xenopus oocyte assessed as potentiation of 200 uM ACh-induced current at holding po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataEC50:  1.00E+3nMAssay Description:Allosteric modulator activity at alpha7 nAChR in human IMR32 cells assessed as stimulation of agonist-induced intracellular calcium level by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataEC50:  212nMAssay Description:Positive allosteric modulatory activity against alpha7 nAChR in human IMR-32 cells assessed as potentiation of PNU-282987-induced Ca2+ efflux at by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Instituto De Qu£Mica M£Dica (Iqm-Csic)

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataEC50:  600nMAssay Description:Agonist activity at recombinant human nAChRalpha7 expressed in HEK293 Flip-In cells co-expressing RIC3 assessed as increase in intra cellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50250187(4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrr...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed