BDBM50277551 A-839977::CHEMBL1628691

SMILES Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1

InChI Key InChIKey=GMVNBKZQJFRFAR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50277551   

TargetP2X purinoceptor 7(Human)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM50277551(A-839977 | CHEMBL1628691)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human 1321N1 cells assessed as reduction in agonist-induced intracellular Ca2+ levels preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM50277551(A-839977 | CHEMBL1628691)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human THP1 cells assessed as reduction in BzATP-induced IL-1beta levels preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM50277551(A-839977 | CHEMBL1628691)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at mouse P2X7 receptor expressed in human 1321N1 cells assessed as reduction in agonist-induced intracellular Ca2+ levels preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM50277551(A-839977 | CHEMBL1628691)
Affinity DataIC50: 6.60nMAssay Description:Antagonist activity at human P2X7 receptor expressed in human THP1 cells assessed as reduction in BzATP-induced pore formation by measuring YO-PRO up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Rat)
Instituto De Tecnologia Em F£Rmacos

Curated by ChEMBL
LigandPNGBDBM50277551(A-839977 | CHEMBL1628691)
Affinity DataIC50: 20nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in human 1321N1 cells assessed as reduction in agonist-induced intracellular Ca2+ levels preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2020
Entry Details Article
PubMed