BDBM50006202 3-Amino-N-[1-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-3-methyl-butyramide::A-64662::CHEMBL300337::ENALKIREN

SMILES COc1ccc(C[C@H](NC(=O)CC(C)(C)N)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC2CCCCC2)[C@@H](O)[C@@H](O)CC(C)C)cc1

InChI Key InChIKey=KQXVERRYBYGQJZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50006202   

TargetRenin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 2.30nMpH: 7.7Assay Description:Inhibitory activity against renin in monkey plasma at pH 7.7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 14nMpH: 7.4Assay Description:Inhibition of human plasma renin at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of monkey plasma reninMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Bovine Cathepsin D.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetPepsin A(Pig)
Parke-Davis Pharmaceutical Research Division of Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for the percent inhibition of pepsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetRenin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 14nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetCathepsin D(Bovine)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 1.00E+5nMAssay Description:Compound was evaluated for the percent inhibition of Cathepsin D in BovineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetRenin(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006202(A-64662 | CHEMBL300337 | 3-Amino-N-[1-[1-(1-cycloh...)
Affinity DataIC50: 0.760nMAssay Description:Compound was evaluated for inhibition of plasma renin activity in humanMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed