BDBM50331286 2-(5-chloro-1H-indol-3-yl)ethanamine::5-Cl-T::CHEMBL1288716

SMILES NCCc1c[nH]c2ccc(Cl)cc12

InChI Key InChIKey=FVQKQPVVCKOWLM-UHFFFAOYSA-N

Data  2 KI  2 IC50  4 EC50

PDB links: 4 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50331286   

TargetSodium-dependent serotonin transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataEC50:  19nMAssay Description:Induction of 5-HTT-mediated 5-HT release in rat brain synaptosomes by [3H]5-HT release assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTransporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of NET-mediated norepinephrine release in rat brain synaptosomes by [3H]NE release assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataEC50:  476nMAssay Description:Induction of DAT-mediated dopamine release in rat brain synaptosomes by [3H]DA release assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at 5HT2A receptor (unknown origin) by cell based calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataIC50: 2.15E+4nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of menthol-induced 45calcium influx treated 5 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataIC50: 3.22E+4nMAssay Description:Antagonist activity at human TRPM8 receptor expressed in human T-REx-293 cells assessed as inhibition of icilin-induced 45calcium influx treated 5 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataKi:  6.21nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50331286(CHEMBL1288716 | 5-Cl-T | 2-(5-chloro-1H-indol-3-yl...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed