BDBM50005536 42-548::5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol::5-(4-chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol::5-Thiophen-2-yl-2,3,5,6-tetrahydro-imidazo[2,1-a]isoquinolin-5-ol::CHEMBL781::MAZINDOL::Mazanor::Sanorex::mazindole

SMILES OC1(N2CCN=C2c2ccccc12)c1ccc(Cl)cc1

InChI Key InChIKey=ZPXSCAKFGYXMGA-UHFFFAOYSA-N

Data  44 KI  29 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 74 hits for monomerid = 50005536   

TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 12.9nMAssay Description:Ability to displace [3H]WIN-35428 from dopamine transporter on rat striatal membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 22nMAssay Description:Inhibition of [3H]WIN-35428 binding to human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter in rat striatal tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University of North Carolina

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 234nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 290nMAssay Description:Inhibition of [3H]WIN-35065-2 binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 231nMAssay Description:Compound was tested for inhibition of [3H]5-HT reuptake at Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 42.6nMAssay Description:Compound was tested for inhibition of [3H]WIN-35428 binding at the dopamine transporter in rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 42.6nMAssay Description:Ability to displace [3H]WIN-35428 from dopamine transporter on guinea pig striatal membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Faes Farma

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 1A receptor (5-HT1A) by displacement of [3H]8-OH-DPAT from rat hippocampus membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 22.1nMAssay Description:Displacement of [3H]WIN-35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Faes Farma

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor by displacement of [3H]-ketanserin from rat prefrontal cerebral cortex mambranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 8.10nMAssay Description:Ability to displace [3H]WIN-35428 from dopamine transporter in rat caudate putamen tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 22.1nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in CHO cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of NE uptake in HEK cells expressing human noradrenaline transporter (hNET)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 42.6nMAssay Description:Ability to displace [3H]WIN-35428 from Dopamine Transporter in guinea pig striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKd:  8.60nMAssay Description:Binding affinity to a single, sodium-dependent site on the Dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 94nMAssay Description:Inhibition of 5-HT uptake in HEK cells expressing human serotonin transporter (hSERT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 8.10nMAssay Description:Ability to displace [3H]WIN-35428 from Dopamine Transporter of rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 43nMAssay Description:Inhibition of dopamine uptake in HEK cells expressing human dopamine transporter (hDAT)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Mouse)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse DAT expressed in HEK293 cells assessed as reduction in [3H]-DA uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of recombinant human NET expressed in HEK293 cell membranes assessed as reduction in [3H]-norepinephrine uptake incubated for 22 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 7nMAssay Description:Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 77nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 85nMAssay Description:Inhibition of [3H]dopamine uptake at the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human SERT expressed in HEK293 cell membranes assessed as reduction in [3H]5-HT uptake incubated for 22 mins by micro beta ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human DAT expressed in HEK293 cell membranes assessed as reduction in [3H]-DA uptake incubated for 22 mins by micro beta sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  0.460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  0.470nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetTransporter(Rat)
Faes Farma

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against norepinephrine transporter (NET) by displacement of [3H]nisoxetine in male wistar ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  1.79nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  1.93nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  2.88nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  11.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  13nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  13.5nMAssay Description:Inhibition of [3H]mazindol binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]mazindol binding to recombinant human NET expressed in HEK293 cell membranes preincubated for 10 mins followed by radioligand addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2019
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  14.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2012
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  15.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2012
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]RTI-55 from human Norepinephrine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Drew University

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  18nMAssay Description:Inhibition of [125I]- RTI -55 binding at the Norepinephrine transporter sites on HEK-hNET cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  22.1nMAssay Description:Displacement of [3H]-WIN-35428 from human DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(Mazanor | 42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro...)
Affinity DataKi:  22.1nMAssay Description:Displacement of [3H]WIN-35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
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