BDBM50317425 10-Gingerol::CHEMBL549472

SMILES CCCCCCCCC[C@H](O)CC(=O)CCc1ccc(O)c(OC)c1

InChI Key InChIKey=AIULWNKTYPZYAN-UHFFFAOYSA-N

Data  1 KI  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50317425   

TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 2.49E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 2.08E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 9.83E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes using Coumarin as substrate preincubated for 10 mins followed by NADPH addition measured after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 5.49E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Hanyang University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2019
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataIC50: 1.26E+5nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction incubated in sodium phosphate buffer at pH 6.2 in presence of NADPHMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Department of Chemistry and Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50317425(10-Gingerol | CHEMBL549472)
Affinity DataKi:  3.74E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed