BDBM14390 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::US11897890, Compound sildenafil::Viagra
SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
InChI Key InChIKey=BNRNXUUZRGQAQC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 200 hits for monomerid = 14390
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Plexxikon
Plexxikon
Affinity DataIC50: 1.50E+3nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M](Human)
Plexxikon
Plexxikon
Affinity DataIC50: 2.00E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)(Human)
Plexxikon
Plexxikon
Affinity DataIC50: 1.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Plexxikon
Plexxikon
Affinity DataIC50: 2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetIsoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489](Human)
Plexxikon
Plexxikon
Affinity DataIC50: 6.10E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMpH: 7.4 T: 2°CAssay Description:PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [535-860](Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataIC50: 2.40nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [1-662,679-875](Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataIC50: 5.90nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [1-660,682-875](Human)
University of North Carolina At Chapel Hill
University of North Carolina At Chapel Hill
Affinity DataIC50: 188nMpH: 7.8 T: 2°CAssay Description:Enzymatic activity of the isolated catalytic domains of wild type PDE5A1 and its deletion mutants was assayed by using [3H]cGMP as substrate in a rea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of Phosphodiesterase 5 from human corpus cavernosumMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibitory activity against phosphodiesterase 5 (PDE5) isolated from canine lungMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDE5 from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of phosphodiesterase 5 of rabbit plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against phosphodiesterase 5 (PDE5) from human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibitory concentration against human phosphodiesterase 5 (PDE5) enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Schering-Plough Research Institute
Curated by ChEMBL
Schering-Plough Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of PDE5 in human platelets after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of phosphodiesterase type 5 (PDE5) of human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Phosphodiesterase 4More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Phosphodiesterase 3More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B(Bovine)
Bayer
Curated by ChEMBL
Bayer
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 4 (PDE4) from rat kidneyMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B(Bovine)
Bayer
Curated by ChEMBL
Bayer
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase 1 from bovine, calmodulinMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory concentration against phosphodiesterase 3 from human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human Phosphodiesterase 5 (n=2-3)More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of bovine Phosphodiesterase 6 (n=2-3)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory concentration against human platelet Phosphodiesterase 5 was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PDE5 of human plateletsMore data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Relaxant effect on rabbit corpus cavernosal tissue stripsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant PDE4 (Phosphodiesterase 4)More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of bovine retina PDE6 (Phosphodiesterase 6)More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B(Bovine)
Bayer
Curated by ChEMBL
Bayer
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine aorta PDE1 (Phosphodiesterase 1)More data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Inhibition of phosphodiesterase 5More data for this Ligand-Target Pair