BDBM50180753 (5-benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester::CHEMBL685::MBDZ::MEBENDAZOLE::Vermox::methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate

SMILES COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c1ccccc1

InChI Key InChIKey=OPXLLQIJSORQAM-UHFFFAOYSA-N

Data  2 KI  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50180753   

TargetMethionine aminopeptidase(Escherichia coli (strain K12))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Co2+ loaded MetAP expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of VEGFR2-mediated angiogenesis in human HUVEC cells after 24 hrs by inverted photomicroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of VEGFR2 after 60 mins by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 670nMAssay Description:Inhibition of Toxoplasma gondii CDPK1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ABLMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human VEGFR2 (789 to 1356 residues) assessed as reduction in autophosphorylation at Y1175 residues using poly (Glu4Tyr1) peptide and AT...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibition of human ABL by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50180753(methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate |...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human SRC by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed