BDBM81939 CAS_52-53-9::NSC_62969::VERAPAMIL
SMILES COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI Key InChIKey=SGTNSNPWRIOYBX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 173 hits for monomerid = 81939
Affinity DataIC50: 141nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 3.53E+3nMAssay Description:MDCK-MDR1 or MDCK-MRP1 cells (50,000 cells per well) were seeded into black CulturePlate (96-well plate) with 100 μL medium and allowed to becom...More data for this Ligand-Target Pair
Affinity DataIC50: 1.73E+5nMT: 2°CAssay Description:For the data shown, 25 nM BD-verapamil was added to various P-gp nanodisc concentrations in the presence of 1 μM empty nanodiscs, and 50 nM BD-v...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycopr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+4nMAssay Description:Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in t...More data for this Ligand-Target Pair
Affinity DataIC50: 143nMAssay Description:Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1More data for this Ligand-Target Pair
Affinity DataIC50: 141nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rabbit)
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to calcium channels in Rabbit cardiac muscle.More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
University of Siena
Curated by ChEMBL
University of Siena
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Ability to inhibit [3H]-PK 11195 binding to peripheral-type benzodiazepine receptor(PBR) in rat cerebral cortex homogenate.More data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Compound was tested for inhibition of daunomycin efflux in the resistant human T-lymphoblast cell line CEM vcr1000.More data for this Ligand-Target Pair
Affinity DataEC50: 3.10E+3nMAssay Description:TP_TRANSPORTER: reversal of Vinblastine accumulation (Vinblastine: 0.005 uM) in MDA435/LCC6 MDR1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of (-)-[3H]- D-888 binding to L-type calcium channels in kitten heart ventricle membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 145nMAssay Description:Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open stateMore data for this Ligand-Target Pair
Affinity DataEC50: 1.04E+3nMAssay Description:Reversal of P-gp-mediated multidrug resistance to vinblastine in human CEM/VLB500 cells after 3 days by resazurin assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+4nMAssay Description:Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...More data for this Ligand-Target Pair
TargetChloroquine resistance transporter(malaria parasite P. falciparum)
Australian National University
Curated by ChEMBL
Australian National University
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of chloroquine-resistant Plasmodium falciparum Dd2 CRT expressed in Xenopus laevis oocytes plasma membrane assessed as reduction of [3H]-c...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow cytometryMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of human MDR1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of MRP1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Institute of Organic Synthesis
Curated by ChEMBL
Institute of Organic Synthesis
Curated by ChEMBL
Affinity DataEC50: 3.73E+4nMAssay Description:Modulation of BCRP1 mediated drug efflux in mitoxantrone-resistant human MES-SA cells assessed as accumulation of hoechst 33342 incubated for 15 mins...More data for this Ligand-Target Pair
Affinity DataEC50: 2.78E+4nMAssay Description:Modulation of MRP1 mediated drug efflux in doxorubicin-resistant human H69 cells assessed as accumulation of calcein AM incubated for 15 mins prior t...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology
Curated by ChEMBL
Vietnam Academy of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology
Curated by ChEMBL
Vietnam Academy of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 398nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology
Curated by ChEMBL
Vietnam Academy of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology
Curated by ChEMBL
Vietnam Academy of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 481nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of MRP1 (unknown origin) expressed in MDCK cells after 30 mins by Calcein-AM assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in Chinese hamster ovary cells heterologically expressing alpha-1C subu...More data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estradiol-17beta-glucuronide substrateMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 6.40E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using pitavastatin substrateMore data for this Ligand-Target Pair
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataIC50: 6.00E+5nMAssay Description:Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells using estrone-3-sulfate substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa...More data for this Ligand-Target Pair
Affinity DataIC50: 4.15E+4nMAssay Description:Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNAMore data for this Ligand-Target Pair
Affinity DataEC50: 385nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vincristine resistance measured as cell survival ...More data for this Ligand-Target Pair
Affinity DataEC50: 503nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing vinblastine resistance measured as cell survival ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 143nMAssay Description:Inhibition of hERG K channelMore data for this Ligand-Target Pair
Affinity DataEC50: 446nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing paclitaxel resistance measured as cell survival a...More data for this Ligand-Target Pair
Affinity DataEC50: 245nMAssay Description:Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversing doxorubicin resistance measured as cell survival ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.33E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 8 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 164nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 790nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Guinea pig)
University of Oxford
Curated by ChEMBL
University of Oxford
Curated by ChEMBL
Affinity DataIC50: 940nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair