BDBM23954 5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoic acid::CHEMBL494::ILOPROST::Ventavis::[3H]-Iloprost

SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O

InChI Key InChIKey=HIFJCPQKFCZDDL-UHFFFAOYSA-N

Data  20 KI  7 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 23954   

TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant Prostanoid IP receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human EP1 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  2.09E+3nMAssay Description:Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of c...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human IP expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cA...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin D2 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  2.06E+3nMAssay Description:Agonist activity at human DP1 expressed in human 1321N1 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins additio...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  0.690nMAssay Description:Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by H...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 9nMAssay Description:Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataEC50:  147nMAssay Description:Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]iloprost from human recombinant IP receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 8.40nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 13nMAssay Description:Binding affinity to PGI2 receptor (unknown origin) by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]iloprost from Prostaglandin I2 receptor of human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataIC50: 27nMAssay Description:Prostaglandin I2 receptor binding by displacement of [3H]iloprost from human plateletsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetProstacyclin receptor(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-iloprost from recombinant rat IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation count...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  4.80nMAssay Description:Binding affinity to human PGI2 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  6.5nMAssay Description:In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]iloprost radioligand from cloned human IP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  6.5nMAssay Description:Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstacyclin receptor(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  11nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP1 subtype(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  56nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Bovine)
Alcon Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  265nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  284nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  619nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHematopoietic prostaglandin D synthase(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  1.04E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  1.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP2 subtype(Human)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  1.87E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP4 subtype(Mouse)
Kyoto University

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  2.30E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E2 receptor EP3 subtype(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  3.70E+3nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP3v6 receptor expressed in HEK293 cell membranes incubated for 1 hr by top count scintillation coun...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier organic anion transporter family member 2A1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM23954(CHEMBL494 | ILOPROST | 5-[(2E,3aS,4R,5R,6aS)-5-hyd...)
Affinity DataKi:  6.49E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed