BDBM50366799 TUBOCURARINE::TUBOCURARINE CHLORIDE

SMILES COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c23)cc7)N(C)CCc6cc5OC)c4

InChI Key InChIKey=JFJZZMVDLULRGK-UHFFFAOYSA-O

Data  3 KI  12 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50366799   

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 9.20E+3nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in HEK-tsA201 cells assessed as inhibition of epibatidine-induced intracellular calcium leve...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory activity against nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMultidrug and toxin extrusion protein 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 5.55E+4nMAssay Description:Inhibition of human MATE2K-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSolute carrier family 22 member 2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 7.88E+4nMAssay Description:Inhibition of human OCT2-mediated ASP+ uptake expressed in HEK293 cells after 3 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMultidrug and toxin extrusion protein 1(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataKd:  1.60E+4nMAssay Description:Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 7.50E+3nMAssay Description:The SKCa-blocking action was assessed by its ability to inhibit the after hyperpolarization (AHP) in cultured rat sympathetic neuronesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataIC50: 3.28E+5nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataKi:  4.79E+3nMAssay Description:Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat br...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataKi:  9.20E+3nMAssay Description:Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366799(TUBOCURARINE | TUBOCURARINE CHLORIDE)
Affinity DataKi:  9.72E+3nMAssay Description:Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed