BDBM50240772 (1R,2S)-(-)-2-phenylcyclopropylamine::(1R,2S)-2-phenylcyclopropanamine::(tranylcypromine)2-Phenyl-cyclopropylamine::2-Phenyl-cyclopropylamine::CHEMBL1179::Parnate::TRANYLCYPROMINE::TRANYLCYPROMINE HYDROCHLORIDE::US10836743, Compound TCP::US8993808, Tranylcypromine::US9180183, Tranylcypromine::cid_2723716::rel-Tranylcypromine
SMILES N[C@@H]1C[C@H]1c1ccccc1
InChI Key InChIKey=AELCINSCMGFISI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 122 hits for monomerid = 50240772
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
TargetGuanine nucleotide-binding protein subunit alpha-15(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+3nMpH: 7.5Assay Description:Human recombinant monoamine oxidase proteins MAO-A and MAO-B were purchased from Sigma Aldrich. MAOs catalyze the oxidative deamination of 1, 2 and 3...More data for this Ligand-Target Pair
Affinity DataIC50: 600nMpH: 7.5Assay Description:Human recombinant monoamine oxidase proteins MAO-A and MAO-B were purchased from Sigma Aldrich. MAOs catalyze the oxidative deamination of 1, 2 and 3...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by lumines...More data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by lumines...More data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of human recombinant LSD1 expressed in Escherichia coli using methylated H3K4peptide as substrate incubated for 15 mins prior to substrate...More data for this Ligand-Target Pair
Affinity DataKd: 1.01E+5nMAssay Description:Binding affinity to recombinant LSD1(unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.21E+3nMAssay Description:Inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of MAOA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of recombinant LSD1 (157 to 852) (unknown origin) transfected in Escherichia coli BL21(DE) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomeMore data for this Ligand-Target Pair
Affinity DataKd: 2.30E+3nMAssay Description:Binding affinity to CYP2A13 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Binding affinity to CYP2A6 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human recombinant CYP2B6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human recombinant CYP2B6 expressed in insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human recombinant CYP2B6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant CYP2C19 using CEC as substrate incubated for 50 mins by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant KDM1A using H3K4me2 and ADHP substrate assessed as inhibition of resorufin formation by peroxidase coupled enzyme ass...More data for this Ligand-Target Pair
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 6.96E+3nMAssay Description:Inhibition of human CYP2B6More data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human CYP2B6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Compound was evaluated for inhibition of Microbial tyramine oxidase; competitiveMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration for human liver monoamine oxidase AMore data for this Ligand-Target Pair
Affinity DataIC50: 3.49E+4nMAssay Description:Inhibition of recombinant LSD2 (22 to 822 aa) (unknown origin) expressed in Escherichia coli BL21(DE) by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKd: 4.63E+4nMAssay Description:Binding affinity to human recombinant LSD1 (157 to 852 aa) expressed in Escherichia coli BL21(DE) by microscale thermophoresis assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.78E+4nMAssay Description:Inhibition of human recombinant LSD1 (157 to 852 aa) expressed in Escherichia coli BL21(DE) using H3K4me2 as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.97E+4nMAssay Description:Inhibition of human recombinant LSD1 using dimethylated H3K4 peptide as substrate after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of recombinant full length LSD1 (unknown origin) expressed in Escherichia coli BL21 (DE) using H3K4me2 substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-Mephentoin as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology
Curated by ChEMBL
European Institute of Oncology
Curated by ChEMBL
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using biotinylated H3K4me1 peptide as substrate preincubated for 2...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Human)
European Institute of Oncology
Curated by ChEMBL
European Institute of Oncology
Curated by ChEMBL
Affinity DataIC50: 3.06E+4nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using H3K4me1 peptide as substrate preincubated for 15 mins with e...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of KDM1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of recombinant human MAOA incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human MAOA using (4S)-4, 5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by MAO-Glo ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of human recombinant LSD1 incubated for 30 mins using H3K4me2 peptide substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.54E+3nMAssay Description:Inhibition of human MAOB using (4S)-4, 5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by MAO-Glo ass...More data for this Ligand-Target Pair
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of MAO-A (unknown origin) by luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of MAO-B (unknown origin) by luminescence assayMore data for this Ligand-Target Pair