BDBM50336799 5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue::8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid::8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID::8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid(suramin)::8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid::CHEMBL265502::Germanin::Suramin hexasodium::US8835659, Suramin::Urea derivative::suramin
SMILES Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
InChI Key InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 60 hits for monomerid = 50336799
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant SIRT2 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of SIRT5More data for this Ligand-Target Pair
3D Structure (crystal)TargetProtein arginine N-methyltransferase 1 [11-371](Human)
Sapienza University of Rome
Curated by ChEMBL
Sapienza University of Rome
Curated by ChEMBL
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of human recombinant GST-PRMT1 expressed in BL21 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Aspergillus nidulans recombinant GST-RmtA expressed in BL21 cellsMore data for this Ligand-Target Pair
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei brucei)
National Center For Advancing Translational Sciences
Curated by ChEMBL
National Center For Advancing Translational Sciences
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assayMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of human Sirt5 deacetylation activity using FKRGVL-acetylLys-EYGVKV as substrate after 60 mins by glutamate dehydrogenase-coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human His6-tagged SIRT2 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human GST-tagged SIRT1 expressed in Escherichia coli BL21(DE3) assessed as inhibition of ZMAL conversion to ZML after 4 hrs by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of yeast Hst2 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of human full length SIRT1 expressed in DE3 cells by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as inhibition of UTP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+4nMAssay Description:Antagonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as inhibition of UDP-induced intracellular calcium mobilization b...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human SIRT5 using H3K9 succinyl peptide substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.62E+3nMpH: 8.0Assay Description:50 uM of substrate peptide (acetylated AMC-labeled peptide from p53 residues 379-382, RHKKAc, BioMol. Cat. #KI-177), 91 nM of human SIRT1 (full lengt...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 4.66E+4nMAssay Description:Inhibition of SIRT5 using ZK(suc)A substrate after 1 hr by homogeneous fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of full length recombinant human SIRT1 expressed in Escherichia coli BL21 (DE3) PLysS using Fluor-de-Lys as substrate by fluorimetric assa...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant SIRT1 using ZMAL substrate after 4 hrs by homogeneous fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity against rat P2X2 receptor expressed in Xenopus laevis oocyte assessed as inhibition of alpha, beta-meATP-induced inward current b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human SIRT1 using Fluor-de-Lys as substrateMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Illinois At Chicago
Curated by ChEMBL
University of Illinois At Chicago
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of purified HIV-2 reverse transcriptaseMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois
Curated by ChEMBL
University of Illinois
Curated by ChEMBL
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of HIV1 RTMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus type 1)
University of Illinois
Curated by ChEMBL
University of Illinois
Curated by ChEMBL
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibition of HIV1 recombinant reverse transcriptase p66/p51 expressed in Escherichia coliMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of SARS-CoV-2 RdRp expressed in Escherichia coli BL21 (DE3) cells incubated for 60 mins by fluorescence based assayMore data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of PKM2 (unknown origin)More data for this Ligand-Target Pair
TargetPyruvate kinase PKM(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PKM1 (unknown origin)More data for this Ligand-Target Pair
TargetPyruvate kinase PKLR(Human)
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
National Institute of Pharmaceutical Education and Research Ahmedabad
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of PKL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibitory activity against DNA-DNA dependent protein kinase (DNA-PK)More data for this Ligand-Target Pair
Affinity DataEC50: 9.20E+4nMAssay Description:Antagonist activity against recombinant human P2X purinoceptor 7 (P2X7)More data for this Ligand-Target Pair
Affinity DataEC50: 3.00E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X2) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Evaluated for antagonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytesMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human SIRT5 assessed as reduction in desuccinylase activity using KQTAR(SuK)STGGKA substrateMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human recombinant SIRT5 isoform 1 (34 to 302 amino acids) expressed in Escherichia coli BL21 (DE3) codon plus RIL cells assessed as red...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of SIRT5 (unknown origin) using (DABCYL)ISGASE(SuK)DIVHSE(EDANS)G peptide substrate incubated for 1 hrs followed by 1 hr incubation with t...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
Technical University of Denmark
Curated by ChEMBL
Technical University of Denmark
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of SIRT5 (unknown origin) using (DABCYL)ISGASE(SuK)DIVHSE(EDANS)G peptide substrate incubated for 1 hrs followed by 1 hr incubation with t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of SIRT1 (unknown origin) using AMC-Arg-His-Lys-Lys(Ac) substrate assessed as deacetylation of substrate by fluorimetric enzyme assayMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
National Institutes of Health Chemical Genomics Center
Curated by ChEMBL
Affinity DataEC50: 1.30E+3nMAssay Description:Competitive binding affinity to human PXR LBD (111 to 434) by TR-FRET assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Illinois At Chicago
Curated by ChEMBL
University of Illinois At Chicago
Curated by ChEMBL
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of purified HIV-2 reverse transcriptaseMore data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+4nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)More data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Human)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of Protein kinase C (PKC)More data for this Ligand-Target Pair
Affinity DataIC50: 9.76E+3nMAssay Description:PTP1B tyrosine phosphatise drug discovery kit (BML-AK 822, Enzo life sciences, USA) was utilized for in vitro testing of synthesized compounds agains...More data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)More data for this Ligand-Target Pair
Affinity DataEC50: 4.00E+3nMAssay Description:Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 3 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.49E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: 1.04E+4nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 30 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )More data for this Ligand-Target Pair
Affinity DataEC50: 4.80E+4nMAssay Description:Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+3nMpH: 8.8Assay Description:The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP...More data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 1 (P2X1) at 1 uM, expressed in Xenopus oocytesMore data for this Ligand-Target Pair