BDBM50005835 (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide::1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide::1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide::3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide::3-[2-(dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide::CHEMBL128::SUMATRIPTAN::Sumatran::Sumax
SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
InChI Key InChIKey=KQKPFRSPSRPDEB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 188 hits for monomerid = 50005835
Affinity DataIC50: 59nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Compound was tested for its ability to inhibit forskolin-stimulated activity of adenylate cyclase coupled to human 5-HT 1A receptor in HeLa cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 640nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Binding affinity was measured against serotonin 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 7.94E+3nMAssay Description:Binding activity radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 501nMAssay Description:Binding activity radioligand.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Binding activity radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 77nMAssay Description:Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Binding affinity by displacement to human cloned 5-hydroxytryptamine 1D receptor in CHO cells by [3H]5-HT displacement.More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Mouse)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 450nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Compound was evaluated for the stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
Affinity DataEC50: 97nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30E+3nMAssay Description:Inhibition of forskolin stimulated adenylate cyclase at 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]5-HT binding displacement.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Measurement of agonist induced [35S]GTP-gamma-S, binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptor.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 9.30nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1E(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1E receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 220nMAssay Description:Compound was tested for 5-hydroxytryptamine 1D like receptor-mediated vascular effect in rabbit saphenous vein (RSV)More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 4.30nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Displacement of [3H]5-HT binding from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 14nMAssay Description:Stimulation of [35S]GTP-gamma-S, binding in CHO cells expressing the 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Displacement of [3H]5-HT binding from the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Compound was tested for the displacement of [3H]5-HT binding to cloned 5-hydroxytryptamine 1D receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]5-HT displacement.More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Agonist-induced [35S]- GTPgammaS binding in CHO cells stably transfected with 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 5.30nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase activity in Chinese hamster ovary (CHO) stable cell lines expressing human 5-hydroxytryptam...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1F(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataEC50: 35nMAssay Description:In vitro effective concentration for inhibition of skolin-stimulated adenylate cyclase in cell line expressing human 5-hydroxytryptamine 1F receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 38nMAssay Description:Effective concentration determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor stably transfec...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Compound was tested for its ability to displace [3H]-5-HT binding to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 7.90E+3nMAssay Description:Compound was tested for its ability to displace [3H]mesulergine from 5-hydroxytryptamine 2C receptor in pig cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was tested for its ability to displace [3H]DOB from 5-hydroxytryptamine 2A receptor in rat cortex homogenatesMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Compound was tested for its ability to displace [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in pig cortexMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 501nMAssay Description:Displacement of [3H]8-OH-DPAT binding to 5-hydroxytryptamine 1A receptor from pig cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]5-HT binding to 5-hydroxytryptamine 1D receptor from pig caudate membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Compound was tested for the displacement of [3H]-5-HT to 5-hydroxytryptamine 1D receptor recognition sites in pig caudate membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of radioligand [3H]5-HT binding to 5-hydroxytryptamine 1D receptor in pig caudate membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 398nMAssay Description:Ability to bind to 5-hydroxytryptamine 1A receptor from cloned human expressed in Ha7 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Human)
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp and Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Ability to bind to 5-hydroxytryptamine 1D receptor of calf substantia nigraMore data for this Ligand-Target Pair