BDBM50143558 CHEMBL41355::EZOGABINE::N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester::RETIGABINE::[2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester

SMILES CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N

InChI Key InChIKey=PCOBBVZJEWWZFR-UHFFFAOYSA-N

Data  23 EC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 50143558   

TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  930nMAssay Description:Activation of human Kv7.2 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.84E+3nMAssay Description:Agonist activity at Kv7.2/Kv7.3 (unknown origin) expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at Kv7.2 (unknown origin) expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/member 3(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  4.15E+3nMAssay Description:Agonist activity at rat KCNQ2/3 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at rat KCNQ2 channel expressed in CHO cells by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  2.50E+3nMAssay Description:Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential m...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.12E+4nMAssay Description:Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based ass...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  4.21E+3nMAssay Description:Agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 4(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.98E+3nMAssay Description:Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.72E+3nMAssay Description:Activation of human Kv7.2/Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 5(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  800nMAssay Description:Activation of human Kv7.5 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 3(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  3.90E+3nMAssay Description:Activation of human Kv7.3 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.30E+3nMAssay Description:Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  4.38E+3nMAssay Description:Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  2.17E+3nMAssay Description:Agonist activity at rat KCNQ2 expressed in CHOK1 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 5(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  3.45E+3nMAssay Description:Agonist activity at human KCNQ5 expressed in CHOK1 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPotassium voltage-gated channel subfamily KQT member 4(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  5.90E+3nMAssay Description:Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50: <150nMAssay Description:Activity at Kv 7.2 channel expressed in cloned CHO cells by [86Rb] efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  350nMAssay Description:Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Human)
University Federico Ii of Naples

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  350nMAssay Description:Activation of KCNQ2 (unknown origin) expressed in CHO cells at 10 uM after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.30E+3nMAssay Description:Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mVMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2(Mouse)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  1.30E+3nMAssay Description:Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily KQT member 2/3(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50143558(CHEMBL41355 | N-(2-amino-4-(4-fluorobenzylamino)-p...)
Affinity DataEC50:  430nMAssay Description:Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)