BDBM30130 CHEMBL1201082::CHEMBL41::Fluoxetin::Fluoxetine::Prozac::US9120771, Fluoxetine::cid_62857
SMILES CNCCC(Oc1ccc(cc1)C(F)(F)F)c1ccccc1
InChI Key InChIKey=RTHCYVBBDHJXIQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 263 hits for monomerid = 30130
Affinity DataIC50: 457nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetUbiquitin-conjugating enzyme E2 N(Human)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 2.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 3.58nMpH: 7.4Assay Description:5-HT transporter binding assay for evaluating binding of the compound to the serotonin transporter was carried out using human recombinant serotonin ...More data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.54E+3nMpH: 7.4Assay Description:NE transporter binding assay for evaluating binding of the compound to the norepinephrine transporter was carried out using human recombinant norepin...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 1.00E+4nMpH: 7.4Assay Description:DA transporter binding assay for evaluating binding of the compound to the dopamine transporter was carried out using human recombinant dopamine tran...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]spiperone in rat striatal membranesMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of [3H]peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenateMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 32.4nMAssay Description:Inhibition concentration against [3H]5-HT uptake by human serotonin transporter in JAR cellsMore data for this Ligand-Target Pair
Affinity DataKd: 3.61E+4nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Rat)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of 5HT uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of CYP2C19 (unknown origin) using luciferin tagged substrate preincubated for 10 mins before substrate additionMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 47nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of of human TREK1 expressed in tsA201 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of of human TREK1 expressed in HEK293 cells assessed as reduction in channel currentsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 2.5nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of SERT-mediated serotonin uptake in human JAR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Displacement of [3H] astemizole from human recombinant ERG channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 5.20nMAssay Description:Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Centre De Recherches De Vitry-Alfortville
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Displacement of [3H]5-HT from of SERT in rat midbrain homogenates after 5 mins by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 9.40nMAssay Description:Inhibition of human SERT expressed in JAR cells assessed as serotonin uptakeMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 0.810nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 3.60E+3nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]WIN-35428 and the compound at human transporter-hDATMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataKd: 240nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- nisoxatine and the compound at human Norepinephrine transporterMore data for this Ligand-Target Pair
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human Potassium channel HERG expressed in mammalian cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4.41E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AchEMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 39.4nMAssay Description:Inhibition of [3H]5-HT uptake at human 5-HT transporter expressed in Jar cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of [3H]NA reuptake at NA transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]5-HT reuptake at 5HT transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of [3H]DA reuptake at DA transporter in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Korea Institute of Science and Technology
US Patent
Korea Institute of Science and Technology
US Patent
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair